Phenytoin Ikapharmindo Use In Pregnancy & Lactation

Capsule: Administration in pregnant women with consideration of the possibility congenital malformations, neonatal defects coagulation and haemorrhage in newborns.
Not recommended administration in lactating women, due to phenytoin excreted through breast milk.
Injection: Usage in Pregnancy: A number of reports suggests a possible correlation between administration of antiepileptic drugs and congenital malformation. Therefore the advantages of using the drug in pregnancy should be carefully weighed against the risks to the foetus. Addition of Sodium Phenytoin solution to an infusion is not recommended due to decreasing drug solubility and possible formation of precipitate. Biotransformation occurs in the liver. Early intoxication symptoms were observed in patients with liver function disorders, elderly patients and those with severe disease. A small number of patients when administered Phenytoin showed slow metabolism. The slow metabolism may be caused by a limited quantity of enzymes and lack of enzyme induction, the latter is probably due to genetic factors. Drugs intended for the treatment of tonic-clonic epilepsy are not effective for petit mal epilepsy. If both seizures are present, a combined drug therapy is needed. Each injection of intravenous Sodium Phenytoin should be followed by an injection of sterile saline solution through the same needle or intravenous catheter to avoid local irritation due to the alkalinity of the solution. Continuous infusion should be avoided.